Can the microphone mute button of AVerMedia speakerphone sync with my video conference software?

Yes. The microphone mute button of AVerMedia speakerphone can sync with all conference software. Once you mute the speakerphone, your voice won’t be heard by the person on the other end of the line.
 
Notes:
You might notice that the software display mute option may not sync with speakerphone's mute button (except for Microsoft Teams). Don't worry. If you click on the mute button and see the microphone mute LED indicator remains solid red, your voice would be muted, and people on the other end won't hear you.